Pilot Wiped Film Evaporator kwa Mafuta Apadera: Momwe Mungakwaniritsire Ma Level-Low Residual Solvent Levels

Tangoganizirani izi: Mwakhala miyezi yambiri mukukonza mafuta anu apadera, koma mwapeza zosungunulira zotsalira zomwe zimadutsa malire ovomerezeka pakuyesa komaliza. Njira zachikale zotulutsa nthunzi zimasiya 500-1000 ppm ya zinthu zosakhazikika, zomwe zingawononge kukana kwazinthu komanso kukonzanso kokwera mtengo. Vutoli limakhudza opanga zodzoladzola, zamankhwala, ndi mafakitale azakudya omwe amafunikira zosungunulira pansi pa 10 ppm. The Woyendetsa Wopukutira Mafilimu Evaporator imapereka yankho lotsimikizirika, kuphatikiza ukadaulo wafilimu wopyapyala wokhala ndi zida zovumbulutsa kwambiri kuti akwaniritse zotsalira zosungunulira zotsalira mpaka 5 ppm ndikusunga mafuta osamva kutentha m'mafuta apadera.

Chifukwa Chiyani Njira Zachikhalidwe Zochotsera Zosungunulira Zimalephera Pamafuta Apadera?

Mafuta apadera amapereka zovuta zoyeretsera zomwe zida wamba za distillation sizingathe kuthana nazo bwino. Zida zamtengo wapatalizi, kuphatikiza mafuta ofunikira, zotulutsa za CBD, mafuta a nsomba olemera kwambiri omega, ndi ma botanical concentrates - zili ndi zinthu zomwe zimakhudzidwa ndi kutentha komwe kumatsika kuposa 80 ° C. Ma evaporator amtundu wamba amayika zinthu kuti zizikhala ndi kutentha kwanthawi yayitali, zomwe zimafuna maola 4-6 akukonza nthawi yotentha kwambiri. Kupsinjika kwakanthawi kotenthaku kumayambitsa makutidwe ndi okosijeni amafuta acids osakwanira, kumawononga mbiri yolimba ya terpene, ndikuyambitsa kusintha kwamitundu komwe kumachepetsa mtengo wamsika. Kuonjezera apo, machitidwe ochiritsira amalimbana ndi mawonekedwe apamwamba a viscosity ya mafuta apadera apadera, zomwe zimapangitsa kutentha kosiyana ndi kuchotsa zosungunulira zosakwanira. The Pilot Wiped Film Evaporator amathana ndi zolephera izi kudzera mu kufalikira kwamakina kwa chinthu kukhala filimu yowonda kwambiri yongokhuthala mamilimita 0.3-0.5. Izi zimachepetsa kwambiri nthawi yotentha komanso kutentha kofunikira. Kumene ma evaporator ozungulira angafunike 120 ° C kwa maola atatu, makina opukutidwa amapeza zotsatira zabwino kwambiri pa 75 ° C mu mphindi 15-20 zokha za nthawi yokhalamo. Kupukuta kopitilira muyeso kumalepheretsa kuyipitsa ndikusunga makulidwe a filimu osasinthika ngakhale ndi zida zowoneka bwino mpaka 50,000 cP, kuwonetsetsa kuti kutentha kwamtundu wonse kumatuluka.

• Sayansi Pambuyo pa Ultra-Low Residual Solvent Achievement

Kukwaniritsa milingo ya zosungunulira za sub-10 ppm kumafuna kumvetsetsa mphamvu ya vapor-liquid equilibrium mu makina apadera amafuta. Pilot Wiped Film Evaporator imapanga zinthu zabwino kwambiri kudzera munjira zitatu zolumikizirana. Choyamba, makinawa amasunga ma vacuum mpaka 0.1 Pa (0.001 mbar), kutsitsa kwambiri zosungunulira zotsalira monga ethanol, hexane, ndi methanol ndi 80-100 ° C poyerekeza ndi kuthamanga kwa mumlengalenga. Izi zimathandiza wathunthu zosungunulira vaporization pa kutentha otetezeka tcheru bioactive mankhwala. Chachiwiri, kasinthidwe kafilimu kakang'ono kamene kamapangitsa kuti chiwerengerocho chikhale chapamwamba, ndikufulumizitsa kusamutsidwa kwa misa kuchokera kumadzi kupita ku nthunzi. Ma evaporator achikhalidwe amafikira 10-15 m²/m³ malo olumikizirana, pomwe mawonekedwe opukutidwa amafilimu amapitilira 200 m²/m³. Kuwonjezeka kwa 15 kumeneku kumathandizira kuchotsa zosungunulira mwachangu popanda kufunikira kutentha kwambiri. Chachitatu, kukonzanso kosalekeza kwa evaporation pamwamba ndi ma wipers osinthasintha kumalepheretsa mapangidwe a ndende omwe amatsekera zosungunulira mu zigawo za viscous. Kuyesa paokha kumatsimikizira kuti makina opangidwa bwino a Pilot Wiped Film Evaporator amachepetsa mosalekeza zotsalira za ethanol kuchokera ku 3000 ppm mpaka pansi pa 8 ppm pakadutsa kamodzi ndi mafuta apadera.

Kukopera Ma Parameters Pamapulogalamu Osiyanasiyana Amafuta Apadera

Magulu osiyanasiyana apadera amafuta amafunikira magawo ogwirira ntchito ogwirizana kuti akwaniritse milingo yosungunulira yotsika kwambiri komanso kukhulupirika kwazinthu. Pamafuta ofunikira omwe ali ndi ma monoterpenes osakhazikika, kutentha kwamafuta kuyenera kukhala pansi pa 65 ° C kuti mupewe kutaya kwa terpene komwe kumasintha mbiri yafungo. The Woyendetsa Wopukutira Mafilimu Evaporator zimakwaniritsa izi kudzera mu ntchito yowonjezereka ya vacuum pa 0.1-1.0 mbar yophatikizidwa ndi malo otenthetsera okhala ndi jekete kusunga kutentha kwa ± 1 ° C. Mitengo ya chakudya nthawi zambiri imachokera ku 5-15 kg / h pamayunitsi a labotale, zomwe zimapangitsa kuti mpweya uchotsedwe bwino ndikusunga zotulutsa. Chamba ndi hemp zowonjezera zimakhala zofunikira kwambiri, zomwe zimafuna kuchotsedwa kwa ethanol kapena CO2 zosungunulira zosungunulira mpaka pansi pa 5000 ppm pazamankhwala amtundu wamankhwala ndikusunga cannabinoid potency ndi terpene zovuta. Zida za viscous izi zimapindula ndi masanjidwe apawiri-Pilot Wiped Film Evaporator. Gawo loyamba limagwira ntchito pa vacuum yapakati (10-50 mbar) ndi 85 ° C kuchotsa zosungunulira zambiri, ndikuyika zosungunulira ku 90-95% chiyero. Gawo lachiwiri amagwiritsa ntchito vacuum pazipita (0.1-0.5 mbar) pa 70 ° C pomaliza kupukuta, kukwaniritsa milingo yotsalira zosungunulira 50-200 ppm. Njira yokhazikikayi imalepheretsa kuwonongeka kwa matenthedwe ndikuchotsa kufunikira kwa nthawi yayitali yokonza.

• Mafuta a Nsomba ndi Marine Lipid Processing Requirements

Mafuta apadera ochokera m'madzi okhala ndi EPA ndi DHA amafunikira kusamalidwa bwino pakati pa kuchotsa zosungunulira ndi chitetezo cha okosijeni. Ma lipids opanda unsaturatedwa amathiridwa okosijeni mwachangu akakumana ndi kutentha, okosijeni, ndi kuwala, kutulutsa zokometsera komanso kuchepetsa zakudya. The Pilot Wiped Film Evaporator imachepetsa makutidwe ndi okosijeni kudzera m'mipata yonse ya nthunzi yophimbidwa ndi nayitrogeni komanso kufewetsa nthawi yomweyo kwa zosungunulira zomwe zachotsedwa, kuletsa kulowetsedwa kwa okosijeni panthawi yokonza. Kutentha kwa ntchito kumakhalabe pansi pa 75 ° C ngakhale pokonza mafuta a nsomba yamafuta a ethyl esters okhala ndi 5-10% yotsalira ethanol kuchokera ku esterification. Pakugwiritsa ntchito ndende ya omega-3, kuthekera kwa ma cell a distillation amitundu yotsogola ya Pilot Wiped Film Evaporator imathandizira kuchotsa zosungunulira munthawi yomweyo komanso kulemeretsa kwa EPA/DHA. Dongosolo limagwira ntchito pa 0.1 Pa vacuum ndi kutentha kwa evaporator pamwamba pa 110-130 ° C ndi kutentha kwa condenser kwa 40-50 ° C, kupanga ma molekyulu okwanira amatanthauza njira yaulere yolekanitsa potengera kusiyana kwa kulemera kwa maselo. Njira yophatikizikayi imakwaniritsa 80% omega-3 okhutira ndi ethanol yotsalira pansi pa 10 ppm ndi ma peroxides pansi pa 2 meq/kg, kukumana ndi zofunikira za mankhwala ndi makanda.

Zaukadaulo Zomwe Zimathandizira Zotsatira za Ultra-Low Solvent

Mapangidwe aukadaulo a Pilot Wiped Film Evaporator amaphatikiza zinthu zingapo zofunika zomwe zimasiyanitsa ndi zida zafilimu zoonda. Kumanga kuchokera ku 316L chitsulo chosapanga dzimbiri kumatsimikizira kuti kumagwirizana ndi mafuta apadera a acidic komanso kumathandizira kutsimikizira kutsimikizika kwa ntchito za GMP. Malo onse okhudzana ndi malonda amakwaniritsa Ra <0.8 μm pamwamba, kuteteza kuipitsidwa ndikupangitsa kusintha kwachangu pakati pa mitundu yosiyanasiyana yamafuta. Mapangidwe a jekete yotenthetsera amapereka kutentha kofanana mkati mwa ± 2 ° C pamtunda wonse wa evaporation, kuchotsa malo otentha omwe amatha kuwononga mankhwala okhudzidwa. Wiper system imayimira chinthu chofunikira kwambiri chomwe chimakhudza magwiridwe antchito. Magawo apamwamba kwambiri a Pilot Wiped Film Evaporator amagwiritsa ntchito PTFE kapena masamba apadera opukuta polima okhala ndi chilolezo chosinthika chomwe chimasungidwa pa 0.2-0.3 mm kuchokera pakhoma lamoto. Kuthamanga kwa kasinthasintha nthawi zambiri kumachokera ku 100-300 rpm, kukonzanso filimuyo mosalekeza masekondi 0.2-0.3 aliwonse. Kutembenuka kofulumiraku kumalepheretsa kuwonongeka kwa matenthedwe ndikusunga makulidwe oyenera a filimu kuti azitha kutuluka bwino. Makina owongolera a ABB amapereka kuwunika kolondola komanso kusintha kwa kutentha kwa jekete, kuchuluka kwa vacuum, kuchuluka kwa chakudya, komanso kuthamanga kwa wiper, ndi kuthekera kodula mitengo kuti zilembedwe zovomerezeka.

• Mapangidwe a Vacuum System ndi Zokhudza Kuchita

Kukwaniritsa vacuum ya 0.1 Pa kumafuna mapangidwe apamwamba a vacuum kupitilira zida za labotale. Katswiri Woyendetsa Wopukutira Mafilimu Evaporator kuyikapo kumaphatikizapo masitima apamtunda a vacuum ophatikizira mapampu ozungulira okhala ndi zowuzira mizu komanso mapampu ophatikizira kapena mapampu a turbomolecular kuti atseke. Misampha yoziziritsa yomwe ili pakati pa evaporator condenser ndi vacuum pampu imagwira nthunzi yotsalira yosungunulira, kuteteza mafuta a pampu kuti asaipitsidwe ndikuthandizira kukhazikika kwa vacuum. Kukula koyenera kwa mizere ya vacuum, yomwe nthawi zambiri imakhala 50-80 mm m'mimba mwake pamakina oyendetsa ndege, kumachepetsa kutsika kwamphamvu ndikusunga vacuum mosasinthasintha pamalo omwe amawuka. Kukonzekera kwa vacuum kwanthawi zonse kumatsimikizira kuti ndikofunikira kuti pakhale zosungunulira zotsika kwambiri. Mafuta a pampu amasintha maola 200-300 aliwonse ogwirira ntchito amalepheretsa kuwonjezereka kwa mamasukidwe omwe amachepetsa kupopera bwino. Kuyeretsa msampha wozizira komanso kuyang'ana kwa vacuum kumazindikira komwe kumachokera mpweya womwe umasokoneza kuchuluka kwa vacuum. Makina osamalidwa bwino nthawi zonse amakhala ndi vacuum pansi pa 0.05 Pa, kupereka malire ogwiritsira ntchito pochotsa zosungunulira za sub-10 ppm ngakhale ndi matrices apadera apadera amafuta.

Masanjidwe a Multi-Stage for Maximum Solvent Reduction

Ngakhale makina a Pilot Wiped Film Evaporator omwe ali ndi gawo limodzi amapereka zotsatira zabwino pamagwiritsidwe ambiri, mafuta ena apadera amafunikira kukonzedwa kwamagawo angapo kuti akwaniritse zosungunulira zotsika kwambiri. Mafuta a zomera otengedwa pogwiritsa ntchito hexane kapena petroleum ether nthawi zambiri amakhala ndi 500-2000 ppm zosungunulira zotsalira pambuyo pochira koyamba. Kapangidwe ka filimu yopukutidwa ndi magawo awiri kumapereka njira yabwino yoyeretsera. Gawo loyamba limagwira ntchito pa 5-10 mbar vacuum ndi 90-95 ° C, kuchotsa 95% ya zosungunulira zotsalira ndi kuchepetsa mamasukidwe akayendedwe pochotsa zigawo zowala. Mafuta okhazikika amadyetsedwa mwachindunji mu gawo lachiwiri la Pilot Wiped Film Evaporator lomwe likugwira ntchito pa 0.1-0.5 mbar ndi 70-80 ° C popukuta komaliza mpaka pansi pa 10 ppm zosungunulira zotsalira. Njira yotsatiridwayi imapereka maubwino angapo poyesa gawo limodzi la vacuum yozama kwambiri. Pochotsa zosungunulira zochulukira pa vacuum yocheperako, gawo loyamba limaletsa kuchuluka kwa vacuum kuchokera kuzinthu zambiri za nthunzi. Gawo lachiwiri ndiye bwino amachotsa kufufuza zosungunulira pansi zinthu wokometsedwa kwa zochepa matenthedwe kukhudzana. Nthawi yonse yokonzekera imakhala ndi mphindi 25-35 poyerekeza ndi mphindi 60-90 zofananira ndi gawo limodzi lokonzekera, kuwongolera kwambiri momwe amagwirira ntchito ndikuchepetsa kugwiritsa ntchito mphamvu pafupifupi 40% poyerekeza ndi njira wamba.

• Kuphatikiza ndi Upstream and Downstream Processing

Makina apadera oyeretsera mafuta amaphatikiza Pilot Wiped Film Evaporator ndi zida zowonjezera kuti zitheke bwino. Kukonzekera kumtunda kumaphatikizapo kusefera kuchotsa tinthu tating'onoting'ono tomwe timasokoneza mapangidwe a filimu yopyapyala, kutsatiridwa ndi deaeration kuchotsa mpweya wosungunuka womwe umapanga thovu panthawi ya nthunzi. Tanki yowotchera yokhala ndi mphamvu yowongolera imapangitsa kuti chakudya chisasunthike kupita ku evaporator, chofunikira kuti filimuyo isamachuluke komanso kugawa nthawi yanyumba. Kutentha koyendetsedwa ndi kutentha mpaka 40-60 ° C kumachepetsa kutenthedwa kwa zinthu zomwe zimagwiritsidwa ntchito ndikuwongolera magwiridwe antchito a vacuum. Zipangizo zapansi panthaka zimagwira ndi njira zolekanitsa zosungunulira kuti zibwezeretsedwe ndikugwiritsanso ntchito, kuwongolera njira zachuma komanso magwiridwe antchito a chilengedwe. Ma Condensers omwe amagwira ntchito pa -10 mpaka -20 ° C amatha kugwira bwino ngakhale zosungunulira zotentha kwambiri monga methanol ndi acetone. Zosungunulira zosonkhanitsidwa zimayeretsedwa ndi distillation kuti zibwerere kumtunda wakumtunda, ndikukwaniritsa 98% + mitengo yobwezeretsa zosungunulira. Mafuta apadera oyeretsedwa amachoka mu Pilot Wiped Film Evaporator pa 60-80 ° C, akuyenda molunjika kumalo ozizira ndi kulongedza pansi pa bulangeti la nayitrogeni kuti ateteze oxidation. Njira yophatikizika iyi imathandizira kukonza kosalekeza ndi khalidwe lokhazikika komanso kulowererapo pang'ono pamanja.

Kuwongolera Ubwino ndi Kutsimikizira Kutsata Malamulo

Mafuta apadera opangira mankhwala, chakudya, kapena zodzoladzola amafunikira kuwongolera koyenera komanso kutsimikizika kwadongosolo kuti awonetse ntchito yochotsa zosungunulira mosasinthasintha. Gasi chromatography yokhala ndi sampuli yapamutu kapena jekeseni wachindunji imapereka njira yowunikira yodziwikiratu yotsalira, yokhala ndi malire odziwikiratu pansi pa 1 ppm pazosungunulira wamba. The Woyendetsa Wopukutira Mafilimu Evaporator process validation protocol nthawi zambiri imaphatikizapo qualification ya installing qualification (IQ) yolemba kuyika kwa zida zoyenera, qualification ya operational qualification (OQ) yotsimikizira magwiridwe antchito pamagawo onse ogwirira ntchito, ndi qualification ya performance qualification (PQ) kuwonetsa zotsatira zofananira ndi matrices enieni azinthu. Kuphatikizana kwaukadaulo waukadaulo (PAT) kumathandizira kuyang'anira nthawi yeniyeni ya magawo ofunikira omwe amakhudza kuchotsa zosungunulira. Inline infrared spectroscopy imatha kuzindikira kuchuluka kwa zosungunulira zotsalira pakukonza, kulola kusintha kwachangu kwa chakudya kapena mulingo wa vacuum kuti zisungidwe. Makanema opanikizika ndi kutentha mudongosolo lonselo amapereka kutsimikizika kosalekeza kwa momwe magwiridwe antchito amagwirira ntchito, ndikulowetsa deta yokhazikika yokwaniritsa zofunikira pakutsata kwa FDA 21 CFR Gawo 11. Makonzedwe okhazikika ndi kukonza nthawi zonse amatsimikizira kulondola kwa miyeso, ndi nthawi yofananira ya miyezi 3-6 ya zida zovuta.

Kusanthula kwa Phindu la Mtengo pa Kukwaniritsa Mayeso a Pilot-Scale

Kuyika ndalama mu pulogalamu ya Pilot Wiped Film Evaporator yopangira mafuta apadera kumaphatikizapo kuwunika ndalama zonse komanso ndalama zomwe zimagwiritsidwa ntchito. Makina oyendetsa bwino kwambiri okhala ndi 0.5-1.0 m² malo owoneka ngati nthunzi amachokera ku $80,000-150,000 kutengera masanjidwe, zida zomangira, ndi mulingo wamagetsi. Zowonjezera zina zimaphatikizapo makina opumulira ($ 15,000-30,000), zoziziritsa kuzizira za condenser ($ 8,000-15,000), ndi kuphatikiza kwa malo kuphatikiza zofunikira ndi zowongolera ($10,000-25,000). Ndalama zonse zomwe zimayikidwa nthawi zambiri zimachokera ku $ 120,000-220,000 pamakina athunthu oyendetsa ndege. Kuyika ndalama zazikuluzikuluzi kumapereka phindu lalikulu pantchito poyerekeza ndi matekinoloje ena. Kubwezeretsa kosungunulira kwa 98% + kumachepetsa mtengo wazinthu zopangira ndi $15,000-40,000 pachaka pokonza mafuta apadera a 500-1000 kg pamwezi. Kupulumutsa mphamvu kwa 30-40% kuyerekeza ndi nthunzi yozungulira kumatanthawuza kutsitsa $8,000-15,000 pachaka. Chofunikira kwambiri, Pilot Wiped Film Evaporator imachotsa kutayika kwazinthu kuchokera pakuwonongeka kwamafuta ndikupangitsa mitengo yamafuta apamwamba kwambiri kuti ikwaniritse zosungunulira zolimba. Zopindulitsa zophatikizika nthawi zambiri zimapereka kubweza ndalama mkati mwa miyezi 18-30 kwa opanga mafuta apadera okhazikika.

Kutsiliza

Opanga mafuta apadera omwe akukumana ndi zofunikira zotsalira zosungunulira amapeza Woyendetsa Wopukutira Mafilimu Evaporator imapereka magwiridwe antchito osayerekezeka kuphatikiza ma vacuum apamwamba kwambiri, kuwongolera bwino kutentha, komanso kusamutsa mafilimu opyapyala. Ukadaulowu umakwaniritsa mosalekeza milingo ya zosungunulira za 10 ppm pomwe imasunga zinthu zosagwirizana ndi kutentha, zomwe zimathandiza kutsata malamulo komanso kuyika kwazinthu zamtengo wapatali pazamankhwala, chakudya, ndi zodzikongoletsera.

Gwirizanani ndi Xi'an Well One Chemical Technology Co., Ltd

Kuyambira 2006, Xi'an Well One Chemical Technology Co., Ltd., mothandizidwa ndi Xi'an NewSet Chemical Equipment Technology, yakhazikika pakupanga zida zolekanitsa ndi kuyeretsa. Ofesi yathu ya 1500 m², labotale ya 500 m² R&D, ndi fakitale ya 4500 m² imapereka chitukuko chokwanira, kapangidwe ka zida, kuyesa, ndi ntchito zoyendetsa ndege. Ndi zaka 19 zaukatswiri, timapereka ma distillation a mamolekyulu ndikupukuta makina otulutsa mpweya kuchokera pakuyesa kupita ku mafakitale, kuwonetsetsa kuti ntchitoyo ipanga mphamvu ndi mtundu wake poyesa mwamphamvu.

Kodi mwakonzeka kukwaniritsa zosungunulira zotsalira kwambiri m'mafuta anu apadera? Monga fakitale yotsogola ya China Pilot Wiped Film Evaporator, China Pilot Wiped Film Evaporator supplier, ndi China Pilot Wiped Film Evaporator wopanga, timapereka mayankho ogulitsa ku China Pilot Wiped Film Evaporator. Onani Pilot Wiped Film Evaporator yathu yogulitsa ndi mtengo wampikisano wa Pilot Wiped Film Evaporator ndikupeza makina a High Quality Pilot Wiped Film Evaporator omwe ali ndi miyezo ya CE, ISO, UL, ndi SGS. Zipangizo zathu zimakhala ndi zomangamanga 316 zosapanga dzimbiri, makina owongolera a ABB, 0.1 Pa vacuum kuthekera, ndipo amabwera ndi chithandizo cha OEM & ODM kuphatikiza chitsimikizo cha chaka chimodzi. Timapereka upangiri wapamwamba kwambiri kudzera muzinthu zosankhidwa, R&D yokwanira pakugulitsa, ndi mapangidwe ake okhala ndi makanema ojambula a 3D kuchokera kufakitale yathu ya 5000㎡+. Lumikizanani nafe lero pa info@welloneupe.com kuti mukambirane zofunikira zanu zapadera zopangira mafuta ndikulandila yankho lokhazikika. Sungani tsamba ili kuti lizigwiritsidwa ntchito nthawi zonse zikavuta.

Zothandizira

1. Batistella, CB, Maciel, MRW "Teknoloji ya Molecular Distillation: Zofunika Kwambiri ndi Ntchito Zamakampani." Brazilian Journal of Chemical Engineering, Vol. 15, No. 4, 1998.

2. Hickman, KCD "High-Vacuum Short-Path Distillation: Ndemanga ya Mapangidwe ndi Kupititsa patsogolo Njira." Kupita patsogolo kwa Chemical Engineering, Vol. 44, No. 12, 1948.

3. Perry, RH, Green, DW, Maloney, JO "Perry's Chemical Engineers' Handbook, Edition 7." Mutu pa Zida Zopangira Distillation. McGraw-Hill Professional, 1997.

4. Lutisan, J., Cvengros, J. "Mean Free Path of Molecules on Molecular Distillation." Chemical Engineering Journal, Vol. 56, No. 2, 1995.